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OCR: osteoclast Recently, IL-6 production by cells in t lineage has been implicated as an en autocrine/paracrine factor. There are ursors in abnormal numbers of haemopoietic p disease. the bone marrow of patients with Page sors for This may reflect an increase in the pre its the osteoclast, since the osteoclast shar od. precursor with the mature cells of the osphate There is no abnormality in calcium or homeostasis, See later: . Pathogenesis of Paget's Disease . Clinical Features of Paget's Disease · Treatment of Paget's Disease e · Laboratory Evaluation of Paget's Dis